Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase

B A Schweitzer; P J Loida; R L Thompson-Mize; C A CaJacob; S G Hegde

doi:10.1016/s0960-894x(99)00338-8

Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase

Bioorg Med Chem Lett. 1999 Jul 19;9(14):2053-8. doi: 10.1016/s0960-894x(99)00338-8.

Authors

B A Schweitzer¹, P J Loida, R L Thompson-Mize, C A CaJacob, S G Hegde

Affiliation

¹ Monsanto Company, St. Louis, MO 63167, USA.

PMID: 10450980
DOI: 10.1016/s0960-894x(99)00338-8

Abstract

We describe the synthesis and enzymatic activity of a library of beta-carboxamido phosphonates as inhibitors of imidazole glycerol phosphate dehydratase (IGPD). Biological results suggest the presence of an enzymatic interaction site not previously observed for other inhibitors of IGPD.

MeSH terms

Computer Simulation
Cryptococcus / enzymology
Databases, Factual
Drug Design
Drug Evaluation, Preclinical
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / metabolism
Enzyme Inhibitors / pharmacology*
Hydro-Lyases / antagonists & inhibitors*
Hydro-Lyases / metabolism
Inhibitory Concentration 50
Phenoxyacetates / chemical synthesis*
Phenoxyacetates / pharmacology*
Software
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Phenoxyacetates
Hydro-Lyases
imidazoleglycerolphosphate dehydratase