Abstract
The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described.
MeSH terms
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Administration, Oral
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Animals
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Calcineurin Inhibitors
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Drug Evaluation, Preclinical
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Hypothermia / chemically induced
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Immunophilins / metabolism
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / metabolism
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Immunosuppressive Agents / pharmacology*
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Immunosuppressive Agents / toxicity
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Inhibitory Concentration 50
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Injections, Intravenous
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Kidney Diseases / chemically induced
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Macrolides / chemical synthesis*
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Macrolides / pharmacology*
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Male
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Mice
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Mice, Inbred BALB C
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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Tacrolimus / analogs & derivatives*
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Tacrolimus / chemistry
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Tacrolimus / pharmacology
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Tacrolimus / toxicity
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Tacrolimus Binding Proteins
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Toxicity Tests
Substances
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Calcineurin Inhibitors
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Immunosuppressive Agents
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Macrolides
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immunomycin
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Tacrolimus Binding Proteins
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Immunophilins
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Tacrolimus