A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports

Y L Liao; K Saku; J Ou; S Jimi; B Zhang; K Shirai; K Arakawa

doi:10.1177/000331979905000808

A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports

Angiology. 1999 Aug;50(8):671-6. doi: 10.1177/000331979905000808.

Authors

Y L Liao¹, K Saku, J Ou, S Jimi, B Zhang, K Shirai, K Arakawa

Affiliation

¹ Department of Internal Medicine, Fukuoka University School of Medicine, Japan.

PMID: 10451235
DOI: 10.1177/000331979905000808

Abstract

The authors report five patients with a missense mutation of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp) who have angiographically proven coronary artery disease (CAD). They compare their clinical findings and coronary arteriographic characteristics. They conclude that these case reports show that this mutation is not solely responsible for development of CAD. Diabetes mellitus, smoking, and hyperlipidemia are other risk factors.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Coronary Angiography
Coronary Disease / diagnostic imaging
Coronary Disease / enzymology*
Coronary Disease / genetics*
Coronary Vessels / enzymology*
Electrocardiography
Endothelium, Vascular / enzymology
Female
Follow-Up Studies
Genetic Markers / genetics
Humans
Male
Middle Aged
Mutation, Missense*
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Polymorphism, Genetic
Risk Factors

Substances

Genetic Markers
NOS3 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type III