Abstract
Associations were sought between the presence of allergic sensitivity to Der p 1, a major allergen from the house dust mite, and the HLA-DPB1 genotype. Whilst allergic patients did not differ from controls in DPB1 allelic distribution, there was a correlation of DPB1*11011 with strongly reactive T-cell proliferative responses to Der p 1 and high titre specific IgE to Dermatophagoides pteronyssinus.
MeSH terms
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Alleles*
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Allergens / genetics
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Allergens / immunology
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Animals
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Antigens, Dermatophagoides
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Dust / adverse effects*
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Genotype
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Glycoproteins / genetics
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Glycoproteins / immunology
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HLA-DP Antigens / genetics*
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HLA-DP Antigens / immunology
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HLA-DP beta-Chains
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HLA-DQ Antigens / genetics
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HLA-DQ Antigens / immunology
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics
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HLA-DR Antigens / immunology
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HLA-DRB1 Chains
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Humans
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Hypersensitivity / genetics*
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Immunophenotyping
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Mites / immunology*
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T-Lymphocytes / immunology
Substances
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Allergens
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Antigens, Dermatophagoides
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Dust
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Glycoproteins
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HLA-DP Antigens
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HLA-DP beta-Chains
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HLA-DPB1 antigen
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains