Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent

H Mashiko; S Niwa; H Kumashiro; Y Kaneko; S Suzuki; Y Numata; R Horikoshi; Y Watanabe

doi:10.1046/j.1440-1819.1999.00532.x

Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent

Psychiatry Clin Neurosci. 1999 Apr;53(2):193-4. doi: 10.1046/j.1440-1819.1999.00532.x.

Authors

H Mashiko¹, S Niwa, H Kumashiro, Y Kaneko, S Suzuki, Y Numata, R Horikoshi, Y Watanabe

Affiliation

¹ Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima-City, Japan.

PMID: 10459686
DOI: 10.1046/j.1440-1819.1999.00532.x

Abstract

This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Adult
Antidepressive Agents, Second-Generation / administration & dosage*
Antidepressive Agents, Second-Generation / adverse effects
Depressive Disorder / drug therapy*
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Personality Inventory
Sleep Initiation and Maintenance Disorders / drug therapy*
Trazodone / administration & dosage*
Trazodone / adverse effects
Treatment Outcome

Substances

Antidepressive Agents, Second-Generation
Trazodone