Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives

E I Kvasyuk; I A Mikhailopulo; R J Suhadolnik; E E Henderson; N F Muto; K T Iacono; J Homon; W Pfleiderer

doi:10.1080/07328319908044760

Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1483-4. doi: 10.1080/07328319908044760.

Authors

E I Kvasyuk¹, I A Mikhailopulo, R J Suhadolnik, E E Henderson, N F Muto, K T Iacono, J Homon, W Pfleiderer

Affiliation

¹ Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, Belarus.

PMID: 10474228
DOI: 10.1080/07328319908044760

Abstract

Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.

MeSH terms

Adenine Nucleotides / chemical synthesis*
Adenine Nucleotides / pharmacology
Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / pharmacology
Biopolymers
Dideoxyadenosine / chemistry*
HIV Reverse Transcriptase / antagonists & inhibitors
Oligoribonucleotides / chemical synthesis*
Oligoribonucleotides / pharmacology
Polymerase Chain Reaction
Reverse Transcriptase Inhibitors / chemical synthesis*
Reverse Transcriptase Inhibitors / pharmacology

Substances

Adenine Nucleotides
Anti-HIV Agents
Biopolymers
Oligoribonucleotides
Reverse Transcriptase Inhibitors
Dideoxyadenosine
2',5'-oligoadenylate
HIV Reverse Transcriptase