Abstract
Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on less active ketoderivatives used as starting materials.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bibenzyls / chemical synthesis*
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Bibenzyls / chemistry
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Bibenzyls / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Stilbenes*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Bibenzyls
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Stilbenes
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combretastatin