Antioxidant protection against iron toxicity: plasma changes during cardiopulmonary bypass in neonates, infants, and children

Free Radic Res. 1999 Aug;31(2):141-8. doi: 10.1080/10715769900301651.

Abstract

Cardiopulmonary bypass surgery is associated with the release of low molecular mass iron, which increases the saturation of plasma transferrin to over 50% in all adult patients treated. In a significant minority, however plasma transferrin becomes 100% iron saturated and non-transferrin bound iron can be detected in the plasma. An iron-saturated transferrin is also a common physiological finding in normal term and pre-term infants at a time when their plasma antioxidants, which protect against iron toxicity and radical scavenging, are profoundly different from those seen in adults. This study was conducted to assess the extent to which antioxidants, which protect against iron toxicity, are altered in neonates, infants, and children undergoing cardiopulmonary bypass surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / metabolism*
  • Cardiopulmonary Bypass*
  • Ceruloplasmin / metabolism
  • Child
  • Child, Preschool
  • Female
  • Free Radical Scavengers
  • Humans
  • Infant
  • Infant, Newborn
  • Iron / adverse effects*
  • Iron / blood*
  • Male
  • Reference Values
  • Sulfhydryl Compounds / blood
  • Transferrin / metabolism

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Sulfhydryl Compounds
  • Transferrin
  • Iron
  • Ceruloplasmin