Abstract
Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological malignancies with high dose, intravenous methotrexate. Clinical management was altered on the basis of GFR in only two cases, both of whom had tumour lysis syndrome. Routine estimations of GFR do not contribute to management.
MeSH terms
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Antimetabolites, Antineoplastic / administration & dosage*
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Antimetabolites, Antineoplastic / adverse effects
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Child
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Cost-Benefit Analysis
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Female
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Glomerular Filtration Rate / drug effects*
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Glomerular Filtration Rate / physiology
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Hematologic Neoplasms / drug therapy
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Humans
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Kidney Diseases / chemically induced
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Kidney Diseases / physiopathology
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Male
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Methotrexate / administration & dosage*
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Methotrexate / adverse effects
Substances
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Antimetabolites, Antineoplastic
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Methotrexate