The transformation of the Zagreb University Medical School into an independent medical school, i.e., Split University Medical School prompted us to develop a new curriculum which had to adapt Zagreb curriculum to the new circumstances and to overcome its weaknesses. Additional reasons for new curriculum were the need for implementation of the current trends in medical education and adaptation to the Split Faculty. Principles according which the curriculum was developed took into account the current international recommendations on medical education, equal treatment of all teaching subjects, flexible curriculum and vertical integration of the elective subjects. New curriculum requires substantial changes in the organization of the undergraduate teaching. Because of the differences between Croatian medical schools, it is impossible and unnecessary to have a unique curriculum. Joint effort of medical schools has to be directed to the development of a common curriculum core and corresponding computer base of questions for examinations, enhancing state examination development, standard for the evaluation of the medical schools' quality.