This article contains the data related to diagnosis and treatment of multiple myeloma from several bone marrow transplantation centers. High-dose chemotherapy with stem cell transplantation is currently the best way of treatment in patients with multiple myeloma. The risk factors are chromosomal aberrations, high level of beta-2-microglobulin, CRP and LDH serum levels. The optimal source of stem cells is the blood because of financial and hematological reasons.