[The evaluation of the efficacy of azithromycin and pyrimethamine used alone or in combination in the treatment of an experimental infection in mice by Toxoplasma gondii]

Rev Soc Bras Med Trop. 1999 Jul-Aug;32(4):401-3. doi: 10.1590/s0037-86821999000400011.
[Article in Portuguese]

Abstract

The efficacy of azithromycin and pyrimethamine in experimental infection of mice with Toxoplasma gondii was tested. Daily dosages of 200 mg/kg and 12.5 mg/kg, respectively, were given orally over a period of ten days. The medications were administered in combination or separately. The combined use of the drugs yielded better results, and a similar investigation using a cystogenic strain of the parasite will be conducted in a future study.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Antiprotozoal Agents / therapeutic use*
  • Ascitic Fluid / parasitology
  • Azithromycin / therapeutic use*
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Mice
  • Mice, Inbred BALB C
  • Pyrimethamine / therapeutic use*
  • Toxoplasma / isolation & purification
  • Toxoplasmosis, Animal / drug therapy*
  • Toxoplasmosis, Animal / parasitology

Substances

  • Anti-Bacterial Agents
  • Antiprotozoal Agents
  • Azithromycin
  • Pyrimethamine