Analysis of the Corynebacterium glutamicum dapA promoter

J Bacteriol. 1999 Oct;181(19):6188-91. doi: 10.1128/JB.181.19.6188-6191.1999.

Abstract

Deletion and mutational analysis of the promoter P-dapA from Corynebacterium glutamicum was performed to identify regions and particular nucleotides important for its function. An extended -10 region and a stretch of six T's at positions -55 to -50 were found to be the most important elements in the promoter function. The results of mutational analysis of P-dapA are consistent with the conclusions of statistical computer-aided analysis of 44 C. glutamicum promoter sequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chloramphenicol O-Acetyltransferase
  • Cloning, Molecular
  • Corynebacterium / enzymology
  • Corynebacterium / genetics*
  • DNA Mutational Analysis
  • Gene Expression Regulation, Bacterial
  • Genes, Reporter
  • Hydro-Lyases / genetics*
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • Sequence Deletion

Substances

  • Chloramphenicol O-Acetyltransferase
  • Hydro-Lyases
  • 4-hydroxy-tetrahydrodipicolinate synthase