Abstract
This study investigates the antinociceptive and antihyperalgesic action caused by i.p., i.t. or i.c.v. injections of amiloride when assessed against formalin, capsaicin-induced licking, acetic acid-induced writhing and glutamate-induced hyperalgesia in mice. The systemic, spinal and supraspinal administration of amiloride causes dose-related antinociception when assessed against acetic acid-induced writhing, formalin and capsaicin-induced licking. In addition, amiloride administered by the same routes produced graded inhibition of glutamate-induced hyperalgesia in mice. Together, these results suggest, that amiloride or its derivatives may constitute a strategy for the development of new antinociceptive drugs.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid / pharmacology
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Amiloride / administration & dosage*
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Animals
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Animals, Newborn
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Behavior, Animal / drug effects
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Capsaicin / pharmacology
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Disease Models, Animal
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Diuretics / administration & dosage*
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Dose-Response Relationship, Drug
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Drug Administration Routes
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Formaldehyde / pharmacology
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Glutamic Acid / pharmacology
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Hot Temperature
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Hyperalgesia / chemically induced
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Hyperalgesia / drug therapy*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Injections, Spinal
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Male
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Mice
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Muscle Contraction / drug effects
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Pain / chemically induced
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Pain / drug therapy*
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Pain Measurement / drug effects
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Postural Balance / drug effects
Substances
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Diuretics
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Formaldehyde
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Glutamic Acid
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Amiloride
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Acetic Acid
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Capsaicin