Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a)

K Heermeier; R Schneider; A Heinloth; C Wanner; S Dimmeler; J Galle

doi:10.1046/j.1523-1755.1999.00685.x

Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a)

Kidney Int. 1999 Oct;56(4):1310-2. doi: 10.1046/j.1523-1755.1999.00685.x.

Authors

K Heermeier¹, R Schneider, A Heinloth, C Wanner, S Dimmeler, J Galle

Affiliation

¹ Department of Medicine, Division of Nephrology, University Hospital of Würzburg, Germany.

PMID: 10504482
DOI: 10.1046/j.1523-1755.1999.00685.x

Abstract

We measured oxidative stress caused by lipoproteins in human umbilical vein endothelial cells and rabbit aorta. Oxidized lipoprotein(a) was the more potent stimulus over oxidized low density lipoprotein, and we believe that both influence the pathogenesis of atherosclerosis.

MeSH terms

Animals
Aorta / cytology
Apoptosis / drug effects
Apoptosis / physiology*
Arteriosclerosis / metabolism
Caspase 3
Caspases / metabolism
Cells, Cultured
Endothelium / cytology
Endothelium / enzymology
Humans
Lipoprotein(a) / metabolism
Lipoprotein(a) / pharmacology*
Lipoproteins, LDL / metabolism
Lipoproteins, LDL / pharmacology*
Lysophosphatidylcholines / metabolism
Oxidative Stress / physiology*
Rabbits
Reactive Oxygen Species / metabolism
Superoxide Dismutase / metabolism
Umbilical Veins / cytology

Substances

Lipoprotein(a)
Lipoproteins, LDL
Lysophosphatidylcholines
Reactive Oxygen Species
oxidized low density lipoprotein
Superoxide Dismutase
CASP3 protein, human
Caspase 3
Caspases