Comparison of growth during continuous ambulatory peritoneal dialysis and renal transplantation using conventional immunosuppressive drugs in children

Perit Dial Int. 1998 Jul-Aug;18(4):395-401.

Abstract

Objective: Growth during continuous ambulatory peritoneal dialysis (CAPD) and after renal transplantation (Tx) was assessed in children under the age of 12 years.

Design: Growth was assessed by calculating the standard deviation score for height of normal children of the same age and gender.

Patients: Twenty-one patients undergoing CAPD and 13 patients who had received renal Tx at Kitasato University Hospital.

Results: Overall growth in those children undergoing CAPD and after renal Tx was not good, but growth during CAPD seemed to be slightly better than after renal Tx using conventional immunosuppressive drugs. Only young children who had started CAPD or received renal Tx before the age of 5 years with functioning graft showed catch-up growth, but the final height of these children may still be smaller than normal.

Conclusion: Growth in children with end-stage renal disease is poor but growth during CAPD seems to be slightly better than after renal Tx using conventional immunosuppressive drugs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Azathioprine / therapeutic use
  • Body Height
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Creatinine / blood
  • Cyclophosphamide / therapeutic use
  • Erythropoietin / therapeutic use
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Graft Survival
  • Growth / physiology*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Infant
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery
  • Kidney Failure, Chronic / therapy
  • Kidney Transplantation* / physiology
  • Male
  • Peritoneal Dialysis, Continuous Ambulatory*
  • Prednisolone / therapeutic use

Substances

  • Glucocorticoids
  • Immunosuppressive Agents
  • Erythropoietin
  • Cyclophosphamide
  • Prednisolone
  • Creatinine
  • Azathioprine