Patterns of macrolide resistance determinants among community-acquired Streptococcus pneumoniae isolates over a 5-year period of decreased macrolide susceptibility rates

P Oster; A Zanchi; S Cresti; M Lattanzi; F Montagnani; C Cellesi; G M Rossolini

doi:10.1128/AAC.43.10.2510

Patterns of macrolide resistance determinants among community-acquired Streptococcus pneumoniae isolates over a 5-year period of decreased macrolide susceptibility rates

Antimicrob Agents Chemother. 1999 Oct;43(10):2510-2. doi: 10.1128/AAC.43.10.2510.

Authors

P Oster¹, A Zanchi, S Cresti, M Lattanzi, F Montagnani, C Cellesi, G M Rossolini

Affiliation

¹ Istituto di Clinica delle Malattie Infettive, Sezione di Microbiologia, Università di Siena, 53100-Siena, Italy.

Abstract

Erythromycin resistance rates were found to be increased, from 7.1 in 1993 to 32.8% in 1997, among community-acquired Streptococcus pneumoniae isolates from the Siena area of central Italy. Most of the erythromycin-resistant isolates carried ermAM determinants and were also resistant to josamycin and clindamycin, whereas a minority (5.8%) carried mefA determinants and remained susceptible to the latter drugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Community-Acquired Infections
Drug Resistance, Microbial / physiology
Erythromycin / pharmacology*
Humans
Italy
Microbial Sensitivity Tests
Pneumonia, Pneumococcal / microbiology
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / physiology

Substances

Anti-Bacterial Agents
Erythromycin