Abstract
A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine Triphosphate*
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Models, Molecular
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Molecular Chaperones / metabolism
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Serine Endopeptidases / chemistry
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Serine Endopeptidases / metabolism*
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Structure-Activity Relationship
Substances
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Molecular Chaperones
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Adenosine Triphosphate
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Serine Endopeptidases