Abstract
Although studies of tolerance induction in large animals remain limited compared with murine studies, a number of encouraging observations have been recently reported - especially in nonhuman primate models. The development of antibodies or proteins binding to costimulatory molecules and of an immunotoxin that is active on T cells have been particularly important advances leading to expanded opportunities for extending strategies for tolerance induction to large animals.
MeSH terms
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Abatacept
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Animals
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Antigens, CD / drug effects
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Antigens, Differentiation / drug effects
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B7-1 Antigen / drug effects
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B7-2 Antigen
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Blood Vessels
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Bone Marrow Transplantation
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CTLA-4 Antigen
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Immune Tolerance*
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Immunoconjugates*
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Lymphocyte Activation / drug effects
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Lymphocyte Depletion
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Membrane Glycoproteins / drug effects
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Primates / immunology*
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Signal Transduction / drug effects
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Transplantation, Homologous / immunology*
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Transplantation, Homologous / methods*
Substances
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Antigens, CD
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Antigens, Differentiation
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B7-1 Antigen
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B7-2 Antigen
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CTLA-4 Antigen
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Immunoconjugates
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Membrane Glycoproteins
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Abatacept