Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2715-20. doi: 10.1016/s0960-894x(99)00454-0.

Abstract

A novel series of 5,6,7,8-tetrahydroquinazolines, 4,5,6,7-tetrahydroindazoles and 4,5,6,7-tetrahydrobenzothiazoles has been prepared, having high affinity and selectivity for the dopamine D3 receptor. The 4-methoxy-5,6,7,8-tetrahydroquinazoline 6i and 2-amino-4,5,6,7-tetrahydrobenzothiazole 8 proved to be agonists with among the highest D3 receptor affinities and selectivities reported to date.

MeSH terms

  • Heterocyclic Compounds / chemistry*
  • Heterocyclic Compounds / metabolism
  • Protein Binding
  • Receptors, Dopamine D2 / metabolism*
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes / chemistry*
  • Tetrahydronaphthalenes / metabolism

Substances

  • Heterocyclic Compounds
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes
  • 2-aminotetralin