Abstract
The generation of left-right organ asymmetry during development involves a cascade of signaling events, while the initiating event is not proven, the mechanism of such organ asymmetry involves a number of genetically defined signaling molecules and, potentially specific transcription factors. Development of asymmetry appears to involve regulation of cell migration and proliferation events, and may be mechanistically distinct for different organs, such as pulmonary asymmetry versus cardiac situs. While the precise mechanisms by which genetically linked factors exert their effects still remains incompletely defined, an outline of those events can be deduced.
MeSH terms
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Activin Receptors
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Animals
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Body Patterning / physiology*
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Dyneins / genetics
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Functional Laterality / physiology
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Gene Expression Regulation, Developmental*
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Humans
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Kartagener Syndrome / genetics
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Left-Right Determination Factors
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Microtubules / physiology
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Models, Biological
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Nodal Protein
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Receptors, Growth Factor / genetics
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Signal Transduction*
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Situs Inversus
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Transforming Growth Factor beta / genetics
Substances
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LEFTY1 protein, human
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Left-Right Determination Factors
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NODAL protein, human
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Nodal Protein
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Receptors, Growth Factor
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Transcription Factors
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Transforming Growth Factor beta
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Activin Receptors
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Dyneins