Antioxidant principles from Ephemerantha lonchophylla

J Nat Prod. 1999 Sep;62(9):1225-7. doi: 10.1021/np990025f.

Abstract

One dihydrostilbene and three phenanthrene antioxidants were isolated from an ethanolic extract of the Chinese herbal Ephemerantha lonchophylla. One of these compounds, ephemeranthone (4) is a new natural product. Denbinobin (1) and 3-methylgigantol (3) have been previously isolated from this plant, and 3-ethoxy-5-hydroxy-7-methoxy-1,4-phenanthraquinone (2) is an artifact. The structures of these compounds were determined by spectroscopic analysis. The antioxidative activities for inhibiting human low density lipoprotein oxidation in vitro of compounds 1-4 were determined, and only 4 was active (5.3 times that of probucol).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Humans
  • Lipoproteins, LDL / blood
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Spectrum Analysis

Substances

  • Antioxidants
  • Lipoproteins, LDL