Abstract
Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Base Sequence
-
Chromosomes, Human, Pair 19 / genetics*
-
Cloning, Molecular
-
Exons / genetics
-
Genomic Library
-
Humans
-
Hybrid Cells
-
Introns / genetics
-
Mice
-
Molecular Sequence Data
-
Physical Chromosome Mapping*
-
Polymerase Chain Reaction
-
Potassium Channels / genetics*
-
Potassium Channels, Calcium-Activated*
-
Sequence Homology, Nucleic Acid
-
Small-Conductance Calcium-Activated Potassium Channels
Substances
-
KCNN1 protein, human
-
Potassium Channels
-
Potassium Channels, Calcium-Activated
-
Small-Conductance Calcium-Activated Potassium Channels