Abstract
Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro-inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cytokines / antagonists & inhibitors
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Cytokines / physiology*
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Heart Failure / drug therapy
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Heart Failure / etiology*
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Heart Failure / physiopathology
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Humans
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Inflammation Mediators / antagonists & inhibitors
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Inflammation Mediators / physiology
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Interleukin-1 / physiology
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Interleukin-6 / physiology
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Models, Cardiovascular
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Tumor Necrosis Factor-alpha / physiology
Substances
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Cytokines
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Inflammation Mediators
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Interleukin-1
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Interleukin-6
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Tumor Necrosis Factor-alpha