Abstract
Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Chemistry, Pharmaceutical
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Drug Design
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Drug Therapy*
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Drug-Related Side Effects and Adverse Reactions
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Humans
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Pharmaceutical Preparations / metabolism*
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Pharmacogenetics*
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Pharmacokinetics
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Phenotype
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Polymorphism, Genetic*
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Receptors, Drug / genetics
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Receptors, Drug / metabolism
Substances
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Carrier Proteins
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Pharmaceutical Preparations
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Receptors, Drug