Abstract
A series of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo[3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Anti-Ulcer Agents / pharmacology
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Ethanol / toxicity
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Gastric Acid / metabolism
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Molecular Structure
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Proton Pump Inhibitors
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
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Rats
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Stomach Ulcer / chemically induced
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Stomach Ulcer / prevention & control
Substances
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Anti-Ulcer Agents
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Enzyme Inhibitors
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Proton Pump Inhibitors
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Quinolines
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Ethanol