2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2863-6. doi: 10.1016/s0960-894x(99)00489-8.

Abstract

A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay.

MeSH terms

  • Binding Sites
  • Cell Line
  • Cysteine / chemistry
  • Glutathione / chemistry
  • Humans
  • Leukocyte Elastase / metabolism
  • Molecular Structure
  • Naphthoquinones / chemical synthesis*
  • Naphthoquinones / pharmacology
  • Serine Endopeptidases / metabolism*
  • Serine Proteinase Inhibitors / chemical synthesis*
  • Serine Proteinase Inhibitors / pharmacology
  • Thrombin / metabolism
  • Viral Plaque Assay

Substances

  • Naphthoquinones
  • Serine Proteinase Inhibitors
  • Serine Endopeptidases
  • assemblin
  • Leukocyte Elastase
  • Thrombin
  • Glutathione
  • Cysteine
  • 1,4-naphthoquinone