Abstract
The effect of shark liver oil on cutaneous angiogenesis induced in mice by intradermal grafting of tumour cells was evaluated. It was shown that this substance (Ecomer) suppressed neovascular response in mice grafted with sarcoma L-1 syngeneic cells, human kidney cancer and human urinary bladder cancer cells. In addition, strong stimulatory effect of this drug on mice blood granulocyte number and their metabolic activity was observed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Fish Oils / pharmacology*
-
Fish Oils / therapeutic use
-
Humans
-
Kidney Neoplasms / blood supply*
-
Kidney Neoplasms / drug therapy
-
Kidney Neoplasms / pathology
-
Mice
-
Mice, Inbred BALB C
-
Neovascularization, Pathologic / drug therapy*
-
Sarcoma, Experimental / blood supply*
-
Sarcoma, Experimental / drug therapy
-
Sarcoma, Experimental / pathology
-
Sharks
-
Skin / blood supply*
-
Urinary Bladder Neoplasms / blood supply*
-
Urinary Bladder Neoplasms / drug therapy
-
Urinary Bladder Neoplasms / pathology