Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

J Kizu; M Arakawa; Y Arakawa; F Komoda; M Takamizawa; T Iwata; T Hayakawa; K Imai

doi:10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Biomed Chromatogr. 1999 Nov;13(7):462-4. doi: 10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P.

Authors

J Kizu¹, M Arakawa, Y Arakawa, F Komoda, M Takamizawa, T Iwata, T Hayakawa, K Imai

Affiliation

¹ Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, 3-28-6 Mejirodai, Bunkyo-ku, Tokyo 112-8688, Japan.

PMID: 10534757
DOI: 10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

Abstract

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

MeSH terms

Adolescent
Adult
Asthma / drug therapy
Asthma / metabolism*
Bronchodilator Agents / blood
Bronchodilator Agents / metabolism*
Bronchodilator Agents / pharmacokinetics
Bronchodilator Agents / therapeutic use
Child
Child, Preschool
Chromatography, High Pressure Liquid
Humans
Infant
Middle Aged
Theophylline / blood
Theophylline / metabolism*
Theophylline / pharmacokinetics
Theophylline / therapeutic use

Substances

Bronchodilator Agents
Theophylline