Penile intraepithelial neoplasia overlying Kaposi's sarcoma lesions: role of viral synergy?

Am J Dermatopathol. 1999 Oct;21(5):494-7. doi: 10.1097/00000372-199910000-00018.

Abstract

Several viral agents have been detected in the lesional tissue of Kaposi's sarcoma (KS). Their precise oncogenic role remains to be determined. A 32-year-old heterosexual man with acquired immunodeficiency syndrome (AIDS) who had penile lesions of KS with overlying epithelial changes characteristic of intraepithelial neoplasia associated with concurrent infection by human papillomavirus (HPV) and human herpesvirus 8 (HHV-8) is reported. The absence of viral DNA from uninvolved skin suggests that this coinfection is more than coincidental and may involve synergy between these viruses, as has already been suggested for HPV and herpes simplex 2 virus.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Adult
  • Antigens, CD34 / analysis
  • Factor VIII / analysis
  • Herpesvirus 8, Human / genetics
  • Humans
  • Immunohistochemistry
  • Male
  • Papillomaviridae / genetics
  • Penile Neoplasms / complications
  • Penile Neoplasms / pathology*
  • Penis / chemistry
  • Penis / pathology
  • Penis / virology
  • Platelet Endothelial Cell Adhesion Molecule-1 / analysis
  • Polymerase Chain Reaction
  • Sarcoma, Kaposi / complications
  • Sarcoma, Kaposi / pathology*
  • Sarcoma, Kaposi / virology
  • Skin Neoplasms / complications
  • Skin Neoplasms / pathology*
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / virology

Substances

  • Antigens, CD34
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Factor VIII