Successful liver transplantation from a donor with brodifacoum intoxication

Liver Transpl Surg. 1999 Nov;5(6):509-11. doi: 10.1002/lt.500050610.

Abstract

We describe our use of a liver allograft from a donor who died of intracranial hemorrhage after brodifacoum ingestion. Because brodifacoum can remain in the human body for months, the recipient's posttransplantation coagulation profiles and serum brodifacoum levels were monitored closely. Her posttransplantation course was excellent, with no coagulation problem. At 15 months posttransplantation, she is well, with normal liver function and coagulation profile. We conclude that brodifacoum toxicity is not a strict contraindication to liver donation.

Publication types

  • Case Reports

MeSH terms

  • 4-Hydroxycoumarins / poisoning*
  • Adult
  • Carcinoma, Hepatocellular / surgery
  • Female
  • Humans
  • Intracranial Hemorrhages / chemically induced
  • Liver Neoplasms / surgery
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Rodenticides / poisoning*
  • Tissue Donors
  • Tissue and Organ Procurement

Substances

  • 4-Hydroxycoumarins
  • Rodenticides
  • bromfenacoum