Low dose synthetic human atrial natriuretic peptide infusion in a patient with mitral stenosis and severe pulmonary hypertension

Jpn Circ J. 1999 Oct;63(10):816-8. doi: 10.1253/jcj.63.816.

Abstract

The present report concerns a case of very low plasma levels of atrial natriuretic peptide (ANP) accompanying severe pulmonary hypertension due to mitral stenosis. There was remarkable fibrosis in the atrium and ANP secretion may have been insufficient. Low-dose infusion (0.025 microg kg(-1) min(-1)) of synthetic human alpha-ANP infusion was very effective in improving the pulmonary hypertension.

Publication types

  • Case Reports

MeSH terms

  • Atrial Natriuretic Factor / administration & dosage*
  • Atrial Natriuretic Factor / blood
  • Heart Failure / drug therapy
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / etiology*
  • Hypertension, Pulmonary / therapy
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Mitral Valve Stenosis / complications*
  • Mitral Valve Stenosis / drug therapy*
  • Mitral Valve Stenosis / therapy
  • Pulmonary Wedge Pressure
  • Time Factors

Substances

  • Atrial Natriuretic Factor