Abstract
The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.
MeSH terms
-
Adoptive Transfer
-
Animals
-
Cell Division
-
Cytokines / biosynthesis
-
Histocompatibility Antigens Class II / immunology*
-
Immunization
-
Immunologic Memory*
-
Mice
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Mice, Transgenic
-
Receptors, Antigen, T-Cell / immunology
-
T-Lymphocyte Subsets / cytology
-
T-Lymphocyte Subsets / immunology*
-
Th1 Cells / cytology
-
Th1 Cells / immunology*
-
Th2 Cells / cytology
-
Th2 Cells / immunology*
Substances
-
Cytokines
-
Histocompatibility Antigens Class II
-
Receptors, Antigen, T-Cell