Targeted delivery of antisense oligonucleotides to parenchymal liver cells in vivo

Methods Enzymol. 2000:314:324-42. doi: 10.1016/s0076-6879(99)14113-2.

Authors

E A Biessen¹, H Vietsch, E T Rump, K Fluiter, M K Bijsterbosch, T J van Berkel

Affiliation

¹ Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.

PMID: 10565023
DOI: 10.1016/s0076-6879(99)14113-2

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Asialoglycoproteins / metabolism
Biological Availability
Drug Carriers
Drug Delivery Systems / methods*
Drug Stability
Glycopeptides
Liver / cytology
Liver / drug effects*
Membrane Proteins*
Oligodeoxyribonucleotides, Antisense / administration & dosage*
Oligodeoxyribonucleotides, Antisense / chemistry
Oligodeoxyribonucleotides, Antisense / pharmacokinetics
Orosomucoid / metabolism
Rats
Receptors, Immunologic / metabolism*
Receptors, Lipoprotein*
Receptors, Scavenger
Scavenger Receptors, Class B

Substances

Asialoglycoproteins
Drug Carriers
Glycopeptides
Membrane Proteins
Oligodeoxyribonucleotides, Antisense
Orosomucoid
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scarb1 protein, mouse
Scavenger Receptors, Class B