Case-control study of hospital admission with asthma in children aged 5-14 years: relation with road traffic in north west London

Thorax. 1999 Dec;54(12):1070-4. doi: 10.1136/thx.54.12.1070.

Abstract

Background: Evidence for an association between road traffic pollution and asthma is inconclusive. We report a case-control study of hospital admissions for asthma and respiratory illness among children aged 5-14 in relation to proxy markers of traffic related pollution.

Methods: The study was based on routine hospital admissions data in 1992/3 and 1993/4 for North Thames (West) health region within the M25 motorway. Cases were defined as emergency admissions for asthma (n = 1380) or all respiratory illness including asthma (n = 2131), and controls (n = 5703) were other emergency admissions excluding accidents. Cases and controls were compared with respect to distance of residence from nearest main road or roads with peak hour traffic >1000 vehicles and traffic volume within 150 m of residence, obtained by Geographical Information System techniques. Statistical analysis included adjustment for age, sex, admitting hospital, and a deprivation score for the census enumeration district of residence.

Results: Adjusted odds ratios of hospital admission for asthma and respiratory illness for children living within 150 m of a main road compared with those living further away were, respectively, 0.93 (95% CI 0.82 to 1.06) and 1.02 (95% CI 0.92 to 1.14).

Conclusions: This study showed no association between risk of hospital admission for asthma or respiratory illness among children aged 5-14 and proxy markers of road traffic pollution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / epidemiology
  • Asthma / etiology*
  • Asthma / therapy
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Hospitalization / statistics & numerical data
  • Hospitals, General
  • Humans
  • London / epidemiology
  • Male
  • Odds Ratio
  • Respiration Disorders / epidemiology
  • Respiration Disorders / etiology*
  • Respiration Disorders / therapy
  • Risk Factors
  • Vehicle Emissions / adverse effects*

Substances

  • Vehicle Emissions