[Conformal radiotherapy of prostatic cancer: a general review]

Cancer Radiother. 1999 Sep-Oct;3(5):393-406. doi: 10.1016/s1278-3218(00)87977-9.
[Article in French]

Abstract

Recent progress in radiotherapeutic management of localized prostate cancer is reviewed. Clinical aspects--including dose-effect beyond 70 Gy, relative role of conformal radiation therapy techniques and of early hormonal treatment--are discussed as well as technical components--including patient immobilization, organ motion, prostate contouring, beam arrangement, 3-D treatment planning and portal imaging. The local control and biological relapse-free survival rates appear to be improved by high dose conformal radiotherapy from 20 to 30% for patients with intermediate and high risk of relapse. A benefit of overall survival is expected but not yet demonstrated. Late reactions, especially the rectal toxicity, remain moderate despite the dose escalation. However, conformal radiotherapy demands a high precision at all steps of the procedure.

Publication types

  • Comparative Study
  • English Abstract
  • Review

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Dose-Response Relationship, Radiation
  • Follow-Up Studies
  • Humans
  • Male
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / radiotherapy*
  • Quality Control
  • Radiation Dosage
  • Radiotherapy Planning, Computer-Assisted*
  • Radiotherapy, Conformal*
  • Time Factors

Substances

  • Antineoplastic Agents, Hormonal