Complete response of a gastric primary after a short but toxic course of 'S-1' EORTC Early Clinical Studies Group

Ann Oncol. 1999 Sep;10(9):1117-20. doi: 10.1023/a:1008364601010.

Abstract

We report the case of an unresected, metastatic gastric cancer, which was treated with a very short course of the oral 5-fluorouracil (5-FU) prodrug S-1. The patient had to discontinue chemotherapy during the first treatment cycle due to severe toxicity, but achieved a pathologically confirmed, long-term complete response of her primary tumour, a diffuse-type poorly differentiated adenocarcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / pathology
  • Aged
  • Antimetabolites, Antineoplastic / pharmacology*
  • Drug Combinations
  • Female
  • Fluorouracil / pharmacology*
  • Humans
  • Oxonic Acid / pharmacology*
  • Prodrugs / pharmacology*
  • Pyridines / pharmacology*
  • Remission Induction
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology
  • Tegafur / pharmacology*

Substances

  • Antimetabolites, Antineoplastic
  • Drug Combinations
  • Prodrugs
  • Pyridines
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Fluorouracil