Abstract
Non-syndromic hearing impairment (NSHI) affects approximately 1:2000 newborns and is a significant cause of hearing loss in the elderly. Although the phenotype is quite similar, NSHI is extremely heterogeneous, with over 40 genetic loci now known. A number of the relevant genes have been cloned. These advances are impacting clinical practice and revolutionizing our understanding of the biology of hearing.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromosome Mapping*
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Connexin 26
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Connexins / genetics
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Extracellular Matrix Proteins / genetics
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GPI-Linked Proteins
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Genetic Linkage*
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Hearing Disorders / congenital
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Hearing Disorders / genetics*
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Humans
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Infant, Newborn
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Membrane Glycoproteins / genetics
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Pedigree
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Phenotype
Substances
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Connexins
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Extracellular Matrix Proteins
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GPI-Linked Proteins
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Membrane Glycoproteins
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TECTA protein, human
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Connexin 26