Abstract
The dopaminergic system has been implicated in the aetiology of mood disorders. We conducted family-based association studies for polymorphisms at three genes involved in the metabolism of dopamine: dopamine transporter (DAT1), dopamine-beta-hydroxylase (DBH) and catechol-O-methyl transferase (COMT); and three dopamine receptors: DRD2, DRD3 and DRD5. We used a sample of 122 parent-offspring trios of British Caucasian origin where the proband had bipolar disorder I (BPI), and analysed the results with the transmission/disequilibrium test (TDT) which is robust to hidden population stratification. No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Bipolar Disorder / genetics*
-
Brain / enzymology
-
Brain Chemistry / genetics*
-
Carrier Proteins / genetics
-
Catechol O-Methyltransferase / genetics
-
DNA Primers
-
Dopamine / genetics*
-
Dopamine Plasma Membrane Transport Proteins
-
Dopamine beta-Hydroxylase / genetics
-
England
-
Family Health*
-
Female
-
Genotype
-
Humans
-
Linkage Disequilibrium
-
Male
-
Membrane Glycoproteins*
-
Membrane Transport Proteins*
-
Middle Aged
-
Nerve Tissue Proteins*
-
Penetrance
-
Receptors, Dopamine D1 / genetics
-
Receptors, Dopamine D2 / genetics
-
Receptors, Dopamine D3
-
Receptors, Dopamine D5
-
Synaptic Transmission / genetics
-
Wales
-
White People / genetics
Substances
-
Carrier Proteins
-
DNA Primers
-
DRD3 protein, human
-
DRD5 protein, human
-
Dopamine Plasma Membrane Transport Proteins
-
Membrane Glycoproteins
-
Membrane Transport Proteins
-
Nerve Tissue Proteins
-
Receptors, Dopamine D1
-
Receptors, Dopamine D2
-
Receptors, Dopamine D3
-
SLC6A3 protein, human
-
Receptors, Dopamine D5
-
Dopamine beta-Hydroxylase
-
Catechol O-Methyltransferase
-
Dopamine