Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile

Transplant Proc. 1999 Nov;31(7):2751-3. doi: 10.1016/s0041-1345(99)00552-7.

Authors

H Uchida¹, E Kobayashi, Y Ogino, K Mizuta, H To, R Okabe, K Hashizume, A Fujimura

Affiliation

¹ Division of Organ Replacement Research, Jichi Medical School, Tochigi, Japan.

PMID: 10578276
DOI: 10.1016/s0041-1345(99)00552-7

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Body Weight / drug effects
Fetal Tissue Transplantation / immunology*
Immunosuppressive Agents / pharmacokinetics
Immunosuppressive Agents / therapeutic use
Immunosuppressive Agents / toxicity
Intestines / transplantation*
Male
Mice
Mice, Inbred C57BL
Rats
Rats, Inbred Lew
Tacrolimus / pharmacokinetics*
Tacrolimus / therapeutic use
Tacrolimus / toxicity
Transplantation, Heterologous / immunology*

Substances

Immunosuppressive Agents
Tacrolimus