Abstract
The first syntheses are reported for recently isolated drimanes 11, 12-epoxydrim-8,12-en-11-ol (2) and 11,12-diacetoxydrimane (3), from (-)-sclareol (1). Furthermore, two efficient new routes to the potent bioactive warburganal (4) starting also from 1 are described.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Benzofurans / chemical synthesis*
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Benzofurans / pharmacology
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Diterpenes / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Leukemia P388 / drug therapy
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Naphthalenes / chemical synthesis*
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Naphthalenes / pharmacology
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Porifera / chemistry*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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11,12-diacetoxydrimane
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11,12-epoxydrim-8,12-en-11-ol
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Antineoplastic Agents
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Benzofurans
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Diterpenes
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Naphthalenes
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Sesquiterpenes
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warburganal
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sclareol