Abstract
Two new cytotoxic cembranoid diterpenes, brassicolide (1) and brassicolide acetate (2); a new cytotoxic sesquiterpene, (-)-4alpha-O-acetyl-selin-11-en (3); and six cytotoxic terpenoids, (-)-selin-11-en-4alpha-ol (4), 2-hydroxynephthenol (5), nephthenol (6), cembrene A (7), epoxycembrene A (8), and (-)-beta-elemene (9), have been isolated from the Formosan soft coral Nephthea brassica. The structures of compounds 1-9 were determined by spectral, chemical, and X-ray crystallographic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cnidaria / chemistry*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 2-Ring / isolation & purification*
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Heterocyclic Compounds, 2-Ring / pharmacology
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Humans
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KB Cells
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Methylene Chloride
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Taiwan
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 2-Ring
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brassicolide
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brassicolide acetate
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Methylene Chloride