Abstract
In 22 colostomy-free survivors of curative-intent radiation therapy or chemoradiation for anal carcinoma, measurement of the Gastrointestinal Quality of Life Index (GIQLI) revealed a mean 114 of a maximum 144 points, as compared to 121 in healthy volunteers (n = 150) and 113 in patients with benign anorectal diseases (n = 325). Sixteen patients underwent anorectal manometry to determine anal sphincter length (SL), resting pressure (RP), maximum squeeze pressure (MSP), rectal compliance (RC) and relaxation of the internal anal sphincter (RIAS). SL, RP and MSP were significantly lower in anal carcinoma patients than in healthy volunteers. Complete continence was detected in 56% of patients.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anal Canal / anatomy & histology
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Anal Canal / physiology*
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Anus Diseases / physiopathology
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Anus Diseases / psychology
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Anus Neoplasms / physiopathology
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Anus Neoplasms / psychology
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Anus Neoplasms / radiotherapy*
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Brachytherapy
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Carcinoma, Squamous Cell / physiopathology
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Carcinoma, Squamous Cell / psychology
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Carcinoma, Squamous Cell / radiotherapy*
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Chemotherapy, Adjuvant
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Cohort Studies
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Muscle Contraction / physiology
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Muscle Relaxation / physiology
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Neoplasm Staging
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Pressure
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Quality of Life*
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Radiotherapy Dosage
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Radiotherapy, High-Energy
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Rectal Diseases / physiopathology
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Rectal Diseases / psychology
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Retrospective Studies