Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region

Genomics. 1999 Nov 15;62(1):113-8. doi: 10.1006/geno.1999.6015.

Abstract

We report the identification of a new transcript homologous to the Drosophila staufen protein. This transcript, named STAU2 (HGMW-approved gene symbol and name), maps to the chromosome 8q13-q21 region. The full-length STAU2 cDNA is 4058 bp and contains an open reading frame of 479 amino acids. Analysis of the predicted protein product indicated the presence of three double-stranded RNA-binding domains. Best-fit analysis revealed a 48.5% similarity to the Drosophila protein and a 59.9% similarity to the recently described mammalian homolog hStau, indicating that at least two different transcripts with homologies to the fly protein are present in mammals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Chromosomes, Human, Pair 8 / genetics*
  • DNA, Complementary / genetics
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • Expressed Sequence Tags
  • Gene Duplication
  • Gene Expression
  • Genes*
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Mammals / genetics
  • Molecular Sequence Data
  • Open Reading Frames
  • Protein Structure, Tertiary
  • RNA / metabolism
  • RNA-Binding Proteins / genetics*
  • Sequence Alignment
  • Sequence Homology
  • Species Specificity

Substances

  • DNA, Complementary
  • Drosophila Proteins
  • RNA-Binding Proteins
  • stau protein, Drosophila
  • RNA

Associated data

  • GENBANK/AJ244015
  • GENBANK/AL078636
  • GENBANK/Y19062