Failure of pre-diarrheal antibiotics to prevent hemolytic uremic syndrome in serologically proven Escherichia coli O157:H7 gastrointestinal infection

J Pediatr. 1999 Dec;135(6):768-9. doi: 10.1016/s0022-3476(99)70100-9.

Abstract

A girl had hemolytic uremic syndrome after Escherichia coli O157:H7 infection, despite pre-diarrheal administration of an antibiotic that prevented detectable intestinal colonization. This report casts doubt on the advisability of antibiotic therapy for E coli O157:H7 infections and has implications for our understanding of the mechanism of this disorder.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cefmenoxime / analogs & derivatives*
  • Cefmenoxime / therapeutic use
  • Cephalosporins / therapeutic use*
  • Child
  • Child, Preschool
  • Escherichia coli Infections / complications*
  • Escherichia coli Infections / drug therapy*
  • Escherichia coli O157*
  • Female
  • Hemolytic-Uremic Syndrome / etiology
  • Hemolytic-Uremic Syndrome / prevention & control*
  • Humans
  • Male
  • Time Factors
  • Treatment Failure

Substances

  • Cephalosporins
  • cefteram pivoxil
  • Cefmenoxime