Abstract
Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Apoptosis Regulatory Proteins
-
Cytotoxicity, Immunologic
-
Dendritic Cells / immunology
-
Dendritic Cells / metabolism
-
Dendritic Cells / virology*
-
Humans
-
In Vitro Techniques
-
Measles virus / physiology*
-
Membrane Glycoproteins / genetics*
-
RNA, Messenger / biosynthesis
-
RNA, Messenger / genetics
-
TNF-Related Apoptosis-Inducing Ligand
-
Tumor Necrosis Factor-alpha / genetics*
Substances
-
Apoptosis Regulatory Proteins
-
Membrane Glycoproteins
-
RNA, Messenger
-
TNF-Related Apoptosis-Inducing Ligand
-
TNFSF10 protein, human
-
Tumor Necrosis Factor-alpha