Utility of the monoclonal antibody HIK1083 in the diagnosis of adenoma malignum of the uterine cervix

Gynecol Oncol. 1999 Dec;75(3):345-8. doi: 10.1006/gyno.1999.5622.

Abstract

Objectives: The aim of this study was to qualify a staining technique for the diagnosis of adenoma malignum.

Methods: The gastric mucin expression of adenoma malignum, ordinary endocervical adenocarcinoma, and normal cervical glands was immunohistochemically compared using the monoclonal antibody HIK1083.

Results: The three categories were clearly distinguished, with 90% (9/10) of cases with positive adenoma malignum, 30% (3/10) of cases with weakly positive ordinary cervical adenocarcinoma, and no (0/10) cases of positive normal cervical glands.

Conclusions: This preliminary report indicates that the use of HIK1083 is valuable in the diagnosis of adenoma malignum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / diagnosis*
  • Antibodies, Monoclonal / immunology*
  • Female
  • Humans
  • Immunohistochemistry
  • Mucins / analysis*
  • Mucins / immunology
  • Uterine Cervical Neoplasms / diagnosis*

Substances

  • Antibodies, Monoclonal
  • Mucins