Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine

J Agric Food Chem. 1999 Dec;47(12):4868-72. doi: 10.1021/jf9903206.

Abstract

Twenty-eight kinds of citrus essential oils and their components were studied for inhibitory effects on the formation of N-nitrosodimethylamine (NDMA). The reaction mixture consisted of dimethylamine and sodium nitrite adjusted at pH 3.6, in addition to essential oils and an emulsifying agent. The quantification was determined by high-performance liquid chromatography monitored at 220 nm. All of the essential oils inhibited the formation of NDMA in the range of 20-85%. The oils of ujukitsu (Citrus ujukitsu Hort. ex Shirai), yuzu (C. junos Tanaka), mochiyu (C. inflata Hort. ex Tanaka), and ponkan (C. reticulata Blanco cv. F-2426) inhibited the formation of NDMA much more effectively than other citrus oils. The inhibitory proportions of components of citrus essential oils such as myrcene, alpha-terpinene, and terpinolene were as high as 80%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / chemistry*
  • Chromatography, High Pressure Liquid
  • Citrus / chemistry*
  • Gas Chromatography-Mass Spectrometry
  • Nitroso Compounds / antagonists & inhibitors*
  • Nitroso Compounds / metabolism
  • Oils, Volatile / chemistry*
  • Plant Oils / chemistry*

Substances

  • Anticarcinogenic Agents
  • Nitroso Compounds
  • Oils, Volatile
  • Plant Oils
  • 4-nitrosodimethylaniline