Altered states: programmed proteolysis and the budding yeast cell cycle

P Jorgensen; M Tyers

doi:10.1016/s1369-5274(99)00030-2

Altered states: programmed proteolysis and the budding yeast cell cycle

Curr Opin Microbiol. 1999 Dec;2(6):610-7. doi: 10.1016/s1369-5274(99)00030-2.

Authors

P Jorgensen¹, M Tyers

Affiliation

¹ Programme in Molecular Biology and Cancer, Graduate Department of Molecular and Medical Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, M5G 1X5, M5S 1A8, Canada.

PMID: 10607629
DOI: 10.1016/s1369-5274(99)00030-2

Abstract

The recent identification of an essential RING-H2 finger protein in the SCF E3 ubiquitin ligase complex of budding yeast has uncovered a family of related E3 enzymes, including the other main cell cycle E3 complex, the anaphase promoting complex (APC). Recent insights into APC-dependent proteolysis include a novel protease activity that dissolves cohesion between sister chromatids at anaphase, and a crucial phosphatase, Cdc14, whose release from the nucleolus eliminates cyclin-dependent kinase activity and thereby drives exit from mitosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anaphase-Promoting Complex-Cyclosome
Cell Cycle / genetics
Fungal Proteins / metabolism
Gene Expression Regulation, Fungal*
Ligases / genetics
Ligases / metabolism*
Peptide Synthases / genetics
Peptide Synthases / metabolism*
SKP Cullin F-Box Protein Ligases
Ubiquitin-Protein Ligase Complexes*
Ubiquitin-Protein Ligases
Yeasts / enzymology
Yeasts / genetics*
Yeasts / growth & development*

Substances

Fungal Proteins
Ubiquitin-Protein Ligase Complexes
Anaphase-Promoting Complex-Cyclosome
SKP Cullin F-Box Protein Ligases
Ubiquitin-Protein Ligases
Ligases
Peptide Synthases