Antiplatelet actions of aporphinoids from Formosan plants

Y C Chia; K S Chen; Y L Chang; C M Teng; Y C Wu

doi:10.1016/s0960-894x(99)00593-4

Antiplatelet actions of aporphinoids from Formosan plants

Bioorg Med Chem Lett. 1999 Dec 6;9(23):3295-300. doi: 10.1016/s0960-894x(99)00593-4.

Authors

Y C Chia¹, K S Chen, Y L Chang, C M Teng, Y C Wu

Affiliation

¹ Tajen Institute of Technology, Ping Tung Hsien, Taiwan.

PMID: 10612588
DOI: 10.1016/s0960-894x(99)00593-4

Abstract

Seventeen aporphines were tested for antiplatelet activity. L-(+)-hemovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5'-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 microM against AA-induced platelet aggregation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aporphines / chemistry
Aporphines / isolation & purification*
Aporphines / pharmacology
Molecular Structure
Plants, Medicinal / chemistry*
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / isolation & purification*
Platelet Aggregation Inhibitors / pharmacology
Rabbits

Substances

Aporphines
Platelet Aggregation Inhibitors
aporphine